Search results for " cardiac remodelling"

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The involvement of MMP-2 and MMP-9 in heart exercise-related angiogenesis

2013

Background Little is known about the involvement of matrix metalloproteinases (MMPs) in cardiac vascular remodelling induced by exercise. Our aim was to evaluate and localize MMP-2 and MMP-9’s activities in relation to capillary proliferation in mouse hearts trained for 15, 30 and 45 days. Methods Sixty-three mice were randomly assigned to 7 groups: four control sedentary groups (C0, C15, C30 and C45) and three groups trained by an endurance protocol (T15, T30 and T45). MMP-2 and MMP-9 were examined with zymography and immunostaining analyses. Capillary proliferation was evaluated counting the number of CD31-positive cells. Results Different activity patterns of the latent form of both MMPs…

Malemedicine.medical_specialtyPathologyCapillary growthAngiogenesisNeovascularization PhysiologicBiologyMatrix metalloproteinaseGeneral Biochemistry Genetics and Molecular BiologyVascular remodelling in the embryoNeovascularizationMicePhysical Conditioning AnimalInternal medicineCardiac remodellingmedicineAnimalsAerobic exerciseZymographyMyocardiocyteAerobic trainingMedicine(all)Settore M-EDF/02 - Metodi E Didattiche Delle Attivita' SportiveBiochemistry Genetics and Molecular Biology(all)ResearchCapillary growthGeneral MedicineCoronary VesselsCapillariesPlatelet Endothelial Cell Adhesion Molecule-1Matrix metalloproteinasesEndocrinologyMatrix Metalloproteinase 9Capillary growth Matrix metalloproteinases Aerobic training Myocardiocyte Cardiac remodellingMatrix Metalloproteinase 2Electrophoresis Polyacrylamide Gelmedicine.symptomImmunostainingJournal of Translational Medicine
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Isolation and Characterization of CD276+/HLA-E+ Human Subendocardial Mesenchymal Stem Cells from Chronic Heart Failure Patients: Analysis of Differen…

2012

Mesenchymal stem cells (MSCs) are virtually present in all postnatal organs as well as in perinatal tissues. MSCs can be differentiated toward several mature cytotypes and interestingly hold potentially relevant immunomodulatory features. Myocardial infarction results in severe tissue damage, cardiomyocyte loss, and eventually heart failure. Cellular cardiomyoplasty represents a promising approach for myocardial repair. Clinical trials using MSCs are underway for a number of heart diseases, even if their outcomes are hampered by low long-term improvements and the possible presence of complications related to cellular therapy administration. Therefore, elucidating the presence and role of MS…

Pathologymedicine.medical_specialtyB7 AntigensHeart VentriclesGene ExpressionCell SeparationBiologyCell therapyHLA-EAntigens CDOsteogenesisCellular cardiomyoplastymedicineHumansImmunologic FactorsMyocardial infarctionCells CulturedHeart FailureAdipogenesisMesenchymal stem cells human heart stromal progenitors post-infarct chronic heart failure cardiomyocyte markers immune modulation inflammation cardiac remodelling regenerative medicineSettore BIO/16 - Anatomia UmanaHistocompatibility Antigens Class IMesenchymal stem cellMesenchymal Stem CellsCell BiologyHematologyAnatomymedicine.diseaseClinical trialmedicine.anatomical_structureVentricleHeart failureChondrogenesisBiomarkersDevelopmental BiologyStem Cells and Development
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